Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuros...

Description: Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience) [Hardcover] Koibuchi, Noriyuki and Yen, Paul M. Product Overview Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. Read more Details Publisher ‏ : ‎ Springer; 1st ed. 2017 edition (November 13, 2016) Language ‏ : ‎ English Hardcover ‏ : ‎ 217 pages ISBN-10 ‏ : ‎ 1493937359 ISBN-13 ‏ : ‎ 56 Item Weight ‏ : ‎ 1.07 pounds Dimensions ‏ : ‎ 6.25 x 0.75 x 9.5 inches Best Sellers Rank: #10,085,763 in Books (See Top 100 in Books) #1,347 in Endocrinology #3,591 in Neuroscience (Books) #4,662 in Endocrinology & Metabolism (Books) #1,347 in Endocrinology #3,591 in Neuroscience (Books) We have been selling used books since 2012, and we've learned that the most important thing is doing good business. Honesty is our policy. Free Shipping We ship worldwide. We have multiple warehouses around the world, so please note the extended handling time on certain listings.

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