Novel (Trans)dermal Drug Delivery Strategies: Micro- and Nano-scale Assessments

Description: Novel (Trans)dermal Drug Delivery Strategies by Garvie-Cook Hazel This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This work represents an inventive attempt to apply recent advances innanotechnology to identify and characterise novel polymer systems fordrug delivery through the skin. Atomicforce microscopy (AFM) measurements of the nanoscale mechanicalproperties of topical, drug-containing polymeric films enabled theauthor to identify optimal compositions, in terms of flexibility andsubstantivity, for application to the skin. To elucidatethe enhanced drug release from polyacrylate films incorporating mediumchain triglycerides, the author combined AFM studies with thecomplementary technique of Raman micro-spectroscopy. This experimentalstrategy revealed that the significant increase in thedrug released from these films is the result of a nanoscale two-phasestructure. Finally, in experiments examining the microporation of skinusing femtosecond laser ablation, the author demonstrated that thethreshold at which the skins barrier functionis undermined can be dramatically reduced by the pre-application ofink. The approach allows thermal damage at the pore edge to beminimised, suggesting a very real potential for substantially increasingdrug delivery in a minimally invasive fashion. Back Cover This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skins barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion. Author Biography HazelGarvie-Cook received her M.Phys degree in Physics from DurhamUniversity in 2011 and a PhD in (trans)dermal drug deliverystrategies from the University of Bath in 2014. Since finishing herPhD, she has stayed on at the University of Bath as a ResearchAssociate in the Department of Pharmacy & Pharmacology. Herresearch interests include imaging techniques for investigating drugdelivery to the skin and the changes in topical formulationspost-application. Table of Contents Introduction.-Background.- Methodology.- TEC Plasticization of Topical Polymeric Films.- Lipid Incorporation into Topical PolymericFilms.- Laser Microporation of Skin.- Conclusion. Long Description This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skins barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion. Feature Nominated as an outstanding Ph.D. thesis byUniversity of Bath, UK Reports potentially important advances for transdermal drug delivery Combines methods of physics, chemistry and materials science to the benefit of medical research Details ISBN3319804537 ISBN-10 3319804537 ISBN-13 9783319804538 Format Paperback Series Springer Theses Year 2018 DEWEY 541.2254 Pages 114 Imprint Springer International Publishing AG Place of Publication Cham Country of Publication Switzerland Subtitle Micro- and Nano-scale Assessments Publication Date 2018-03-30 Short Title Novel (Trans)Dermal Drug Delivery Strategies Language English UK Release Date 2018-03-30 Illustrations 24 Illustrations, color; 25 Illustrations, black and white; XVIII, 114 p. 49 illus., 24 illus. in color. Edited by Luv Kohli Birth 1974 Affiliation Massachusetts Institute of Technology Position journalist Qualifications S. J. Author Garvie-Cook Hazel Publisher Springer International Publishing AG Edition Description Softcover reprint of the original 1st ed. 2016 Alternative 9783319289007 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131030908;

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