Human Epigenetics: How Science Works by Carsten Carlberg (English) Paperback Boo

Description: Human Epigenetics: How Science Works by Carsten Carlberg, Ferdinand Molnár The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description The view "Its all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendels experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer.This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described.The book represents an updated but simplified version of our textbook "Human Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease. Back Cover The view "Its all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendels experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics , which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer. This book provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells forming our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook "Human Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease. Author Biography Carsten Carlberg graduated in 1989 with a Ph.D. in Biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland), and docent at the University of Dusseldorf (Germany) he is since 2000 Full Professor of Biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg has projects on epigenome-wide effects of vitamin D on the human immune system.Ferdinand Molnar received his Ph.D. in Biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor− ligand, −protein, and −DNA interactions. In 2018 he moved to the NazarbayevUniversity (Astana, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnars interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease, and recombinant protein production. Table of Contents Introduction.- Chromatin and gene expression.- DNA methylation.- Histone modifications.- Chromatin modifying proteins and RNAs.- Embryogenesis and cellular differentiation.- Population epigenetics and aging.- Cancer epigenetics.- Neuroepigenetics.- Nutritional epigenetics.- Epigenetics of immune function.- Epigenome-environment interactions and their therapy. Feature Is the first undergraduate textbook on epigenetics with a clear focus on humans Links the "hot topic" epigenetics to numerous disciplines, such as embryogenesis, nutrition and neuroscience Describes the impact of epigenetics in health and disease Has a high ratio figures to text Details ISBN3030229068 Author Ferdinand Molnár Language English Year 2019 ISBN-10 3030229068 ISBN-13 9783030229061 Format Paperback Pages 153 Publication Date 2019-10-05 DOI 10.1007/978-3-030-22907-8 UK Release Date 2019-10-05 Edition 1st Imprint Springer Nature Switzerland AG Place of Publication Cham Country of Publication Switzerland Publisher Springer Nature Switzerland AG Edition Description 1st ed. 2019 DEWEY 599.935 Audience Tertiary & Higher Education Illustrations 69 Illustrations, color; XVI, 153 p. 69 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. 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