Developmental Plasticity of Inhibitory Circuitry by Sarah L. Pallas (English) Pa

Description: Developmental Plasticity of Inhibitory Circuitry by Sarah L. Pallas Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. Experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging.The book brings together the work of researchers investigating inhibitory plasticity at many levels of analysis and in several different preparations. This topic is of wide relevance across a number of different areas of research in neuroscience and neurology. Medical problems such as epilepsy, mental illness, drug abuse, and movement disorders can result from malfunctioning inhibitory circuits. Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry. Back Cover Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. Only a few investigators have been engaged in research on how inhibitory circuits are formed during development or how they are involved in plasticity of developing sensory and motor circuitry. Developmental Plasticity of Inhibitory Circuitry approaches the subject of inhibitory plasticity from several levels of analysis, from synapses to circuits to systems to clinical, summarizing several possible mechanisms and collecting some of the most fascinating work in this under-studied area. It is meant to provide an overview for basic and clinical researchers and students interested in neural plasticity and to stimulate further research. About the Editor: Dr. Sarah L. Pallas is a Professor of Neuroscience and Biology at Georgia State University. She earned her Ph.D. in Neurobiology and Behavior at Cornell University, under the tutelage of Dr. Barbara Finlay. Her postdoctoral training was received at M.I.T. in the laboratory of Dr. Mriganka Sur. Her research concerns developmental neurobiology and sensory physiology, and in particular the role of sensory experience in the development and plasticity of neural circuits. Table of Contents The Origins and Specification of Cortical Interneurons.- Role of Spontaneous Activity in the Maturation of GABAergic Synapses in Embryonic Spinal Circuits.- Regulation of Inhibitory Synapse Function in the Developing Auditory CNS.- Developmental Plasticity of Inhibitory Receptive Field Properties in the Auditory and Visual Systems.- Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex.- GABAergic Transmission and Neuronal Network Events During Hippocampal Development.- Endocannabinoids and Inhibitory Synaptic Plasticity in Hippocampus and Cerebellum.- Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders. Review From the reviews:"For basic and clinical researchers and students in neuroscience and neurology, Pallas (neuroscience and biology, Georgia State U) brings together nine chapters that examine how inhibitory circuits are formed during development and how they are involved in plasticity of developing sensory and motor circuitry. … The book originated in a symposium on the topic at the 2006 Society for Neuroscience meeting in Atlanta, Georgia." (SciTech Book News, June, 2010) Long Description Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. Experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. The book brings together the work of researchers investigating inhibitory plasticity at many levels of analysis and in several different preparations. This topic is of wide relevance across a number of different areas of research in neuroscience and neurology. Medical problems such as epilepsy, mental illness, drug abuse, and movement disorders can result from malfunctioning inhibitory circuits. Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry. Review Quote From the reviews:"For basic and clinical researchers and students in neuroscience and neurology, Pallas (neuroscience and biology, Georgia State U) brings together nine chapters that examine how inhibitory circuits are formed during development and how they are involved in plasticity of developing sensory and motor circuitry. ... The book originated in a symposium on the topic at the 2006 Society for Neuroscience meeting in Atlanta, Georgia." (SciTech Book News, June, 2010) Feature Presents latest knowledge in order to reconcile conflicting data and to promote further progress Reports on inhibitory plasticity that has a behavioral implication Seeks to promote further studies to help clarify excitation-independent mechanisms underlying strengthening in inhibitory connections Details ISBN1489982833 Year 2014 ISBN-10 1489982833 ISBN-13 9781489982834 Publication Date 2014-09-09 Format Paperback Short Title DEVELOPMENTAL PLASTICITY OF IN Language English Media Book Imprint Springer-Verlag New York Inc. Place of Publication New York Country of Publication United States Edited by Sarah L. Pallas Edition 2010th Illustrations XI, 190 p. Pages 190 AU Release Date 2014-09-09 NZ Release Date 2014-09-09 US Release Date 2014-09-09 UK Release Date 2014-09-09 Author Sarah L. Pallas Publisher Springer-Verlag New York Inc. Edition Description 2010 ed. Alternative 9781441912428 DEWEY 612.8 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96380106;

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